A Polymorphonuclear Granulocyte is a type of white blood cell that has granules (=small particles) with enzymes in their cytoplasm. They are released during infections, allergic reactions, and asthma. Neutrophils, eosinophils, and basophils are polymorphonuclear granulocytes. They are called polymorphonuclear because of the varying shapes of their nucleus (usually lobed into 3 segments.) As you […]
You may have heard that grape juice can seriously interfere with various medications – including many blood pressure medications. A new study, published in the Journal of Food and Drug Analysis, takes this knowledge a step further by proving that another common juice is even deadlier when used with blood pressure medications. It has already claimed several lives.
As if that wasn’t enough, two more juices were found to completely neutralize the blood pressure medications, causing false security. In a 2016 article that gave practical advice to clinicians in the Natural Medicine Journal, researchers explained that many drugs, upon ingestion, were first processed in your small intestine by a chemical called cytochrome P450 3A4 (CYP3A4) before they started to circulate through your body. This is true for approximately 50% of all drugs. Under normal conditions, these chemicals ensure that these drugs are available in only small amounts, letting them do their work before your liver finally disposes of them and prepares them for excretion.
The big problem with grapefruit juice is that the furanocoumarins and flavonoids in it reduce the activity of CYP3A4. This, in turn, means that the drugs are not first processed by it, and will appear in your body in insanely high and toxic amounts. The consequences of this could include extremely low blood pressure, dangerously irregular heartbeats, unconsciousness, and difficulty breathing. Blood pressure and cholesterol drugs are right at the top of the list of drugs that are processed by CYP3A4, and these can be made toxic through the consumption of grapefruit juice. A small, 200 mL glass of grapefruit juice, or even an entire grapefruit, can make these drugs toxic for anywhere between 24 hours to three days.
Since the first batch of studies, some researchers have found that pmelo, pomegranate, cranberry, and even apple and orange juice can have similar effects. This finding prompted Chinese scientists to do a systematic review of the literature recently, in order to find out just how dangerous blood pressure and cholesterol drugs can be when taken with juice or any fruit other than grapefruit.
They analyzed 46 medical trials.
It was found that the calcium channel antagonist felodipine could become toxic when taken with seville orange juice (also called bitter or sour orange). This popular drug for high blood pressure has even been found to have caused some deaths when taken on the same day as the consumption of this juice. Normal orange juice, in turn, rendered most blood pressure drugs useless by causing them to be excreted before they could be able to do anything. This was true for direct renin inhibitors, like aliskiren, and for beta-blockers, like atenolol and celiprolol. Beta-blockers block the effects of epinephrine (adrenaline) and are often prescribed for cases such as irregular heartbeats, chest pain, and other heart conditions.
Apple juice neutralizes some beta-blockers, and pomelo juice was found to neutralize the drug for high blood pressure, (vasodilator) sildenafil, thereby rendering the drug ineffective. What this new study tells us is that doctors really have no idea as to what interferes with the drugs you’re using.
If something as innocent as apple juice can render your drugs useless, what else could interfere with it?
That is why I always recommend to try to manage your blood pressure naturally as much as possible and to get off medications if you’re already taking them.
Here is the simplest, easiest, and most effective natural method to bring you blood pressure below 120/80 in as little as nine minutes…
What is Thyroglobulin? Thyroglobulin is the protein precursor of thyroid hormone and is made by normal well differentiated benign thyroid cells or thyroid cancer cells. Thyroglobulin is made by normal thyroid cells, and made by most thyroid cancer cells. For example, for patients with papillary or follicular thyroid cancer, nearly all cancer cells make thyroglobulin. […]
Testosterone is a male sex hormone produced in a woman’s ovaries in small amounts as well. Combined with estrogen, the female sex hormone, testosterone helps with the growth, maintenance, and repair of a woman’s reproductive tissues, bone mass, and human behaviors. The normal ranges of testosterone levels for females are: Age (in years) Testosterone range (in nanograms […]
Free thyroxine index is considered to be a reliable indicator of thyroid status in the presence of abnormalities in plasma protein binding. The free thyroxine index has generally been replaced by Free Thyroxine in the assessment of thyroid function, but is occasionally useful when a free T4 result is suspected of being anomalous. Reference ranges for the […]
A good night’s sleep is relaxing and recharging and can, therefore, tackle many diseases, including high blood pressure. However, we will not be discussing sleep in this article. There is something else that happens in your sleep that directly causes high blood pressure. And by fixing this one thing naturally, your blood pressure will automatically return to a healthy level. Even if nothing else has worked in the past.
Up to 30% of people with high blood pressure do not respond to blood pressure medications (even if 3 or 4 types are used) or other traditional “cures” for high blood pressure. At the same time, about 20% of the population has some level of sleep apnea. It is a disease where a person’s breathing passages close up, and they suffocate for a few seconds until the body catches its breath again. This can repeat itself several hundred times during the night. Most people suffering from sleep apnea don’t even know about it. They may just think they had a bad night. Traditional symptoms include daytime tiredness, waking up sluggish, and increased body weight. Loud snoring is very often associated with sleep apnea but not always. Researchers from Ohio State’s Wexner Medical Center, therefore, thought it was possible that sleep apnea was one of the main causes of persistent high blood pressure.
A CPAP (continuous positive airway pressure) machine is the most common way to treat sleep apnea. It ensures that patient’s breathing passages do not close, and they get enough oxygen throughout the night. In their study, the researchers looked at blood pressure numbers from more than 300 patients with resistant, high blood pressure. On the average, their systolic blood pressure went down by more than 7 points and their diastolic blood pressure decreased by almost 5 points when they began using a CPAP machine.
This was after all medications had failed.
If you have high blood pressure that just doesn’t go down, and especially if you often wake up tired, it’s a good idea to stop by your nearest sleep center and have yourself tested for sleep apnea.
There is, however, one more problem:
Even though CPAP machines are very safe and effective in treating sleep apnea, many people feel that using a big mask and machine throughout the night is inconvenient. Some even pull the mask off while sleeping. Therefore, the machine is often not used, and this dangerous disease goes untreated.
However, there is another way to treat sleep apnea.
Years ago, I developed a set of simple, easy stop-snoring exercises. These exercises open up and strengthen the breathing passages. Besides stopping snoring, thousands of readers have reported amazing results for sleep apnea.
You can learn more about (and test drive) these easy 3-minute snoring/ sleep apnea exercises here…
For high blood pressure, I always recommend these easy, blood pressure exercises, guaranteed to lower your blood pressure below 120/80 – starting today…
Protein in the serum is made up of albumin (∼ 60%) and globulin. Globulins are divided into alpha-1, alpha-2, beta, and gamma globulins.Globulins are made in your liver by your immune system. They play an important role in liver function, blood clotting, and fighting infection. In general, alpha and gamma globulin protein levels increase when […]